Unc kl2 program

Institutional K Award Application. You need JavaScript enabled to view it. Sign in UNC Health: sign in. Remember Me. Sign in. Submit a request. This research project is meant to demonstrate both the ability of the candidate to generate a unique question and the ability of the Candidate and mentors to work together. Specify the Facilities Clinical, Animal, Computer, Office, Other to be used for the conduct of the proposed mentored and Scholar-initiated research.

Also include major equipment items already available for this project, noting the location and pertinent capabilities of each. Indicate the performance sites and describe capacities, pertinent capabilities, relative proximity, and extent of availability to the project. The Primary Mentor letter should confirm access. Applicants should identify a Lead Mentor who will have primary responsibility for working with the applicant to assist them in the transition to independent funding.

The goals are 1 to understand how these effects impact on airway diseases, such as asthma, COPD, inhalational injury and airway infection; 2 to learn how these effects trigger cardiovascular disease; and 3 to generate knowledge that informs public policy decisions and develop personal mitigation strategies for susceptible populations. The breadth of experimental models is wide and include in silico, in vitro, animal in vivo, and human clinical studies.

Using these models, investigators aim to examine the effects of environmental agents and inhaled toxicants, including endotoxin, tobacco products, ozone, woodsmoke and other ambient pollutants. Mechanistic, functional, and clinical information on adverse health effects caused by inhaled toxicants is integrated to understand the health effects of inhaled contaminants on the lung and heart.

For descriptions of the investigators and their research programs, please see here. In addition to applied and basic research programs, CEMALB offers educational and research training opportunities for undergraduate and graduate students as well as postdoctoral and clinical fellows.

The Center also facilitates access to the sophisticated in vitro exposure systems and animal environmental exposure facilities of the Public Health and Integrated Toxicology Division of the U. Boucher MD. Researchers use physiologic, genetic, molecular, animal models, and informatics techniques to dissect the pathophysiology of lung disorders.

The contributions to our understanding of cystic fibrosis are numerous and critically important to the recent remarkable advances in the treatment of these patients. In addition, investigators provide Core services including molecular biology, histology, mucin biochemistry, microscopy, CFTR functional analysis, novel human imaging modalities, biospecimen repositories and clinical research services to other investigators on campus and across the country. Although originally developed to study the pathogenesis of cystic fibrosis CF , the Center has grown over the years to include over 40 investigators involved in research involving all aspects of lung biology.

Programs have developed in viral and bacterial infections, acute lung injury and acute respiratory distress syndrome, chronic obstructive pulmonary disease, non-CF bronchiectasis, and many other lung diseases. Strong collaborations between clinical and research faculty has led to remarkable breakthroughs in areas as diverse as COVID, e-cigarette use, acute respiratory distress syndrome, pneumonia, primary ciliary dyskinesia, and more.